Recent attempts to develop and apply digital ethics principles to address the challenges of the digital transformation leave organisations with an operationalisation gap. To successfully implement such guidance, they must find ways to translate high-level ethics frameworks into practical methods and tools that match their specific workflows and needs. Here, we describe the development of a standardised risk assessment tool, the Principle-at-Risk Analysis (PaRA), as a means to close this operationalisation gap for a key level of the ethics infrastructure at (...) many organisations – the work of an interdisciplinary ethics panel. The PaRA tool serves to guide and harmonise the work of the Digital Ethics Advisory Panel at the multinational science and technology company Merck KGaA in alignment with the principles outlined in the company’s Code of Digital Ethics. We examine how such a tool can be used as part of a multifaceted approach to operationalise high-level principles at an organisational level and provide general requirements for its implementation. We showcase its application in an example case dealing with the comprehensibility of consent forms in a data-sharing context at Syntropy, a collaborative technology platform for clinical research. (shrink)

The rapid and dynamic nature of digital transformation challenges companies that wish to develop and deploy novel digital technologies. Like other actors faced with this transformation, companies need to find robust ways to ethically guide their innovations and business decisions. Digital ethics has recently featured in a plethora of both practical corporate guidelines and compilations of high-level principles, but there remains a gap concerning the development of sound ethical guidance in specific business contexts. As a multinational science and technology company (...) faced with a broad range of digital ventures and associated ethical challenges, Merck KGaA has laid the foundations for bridging this gap by developing a Code of Digital Ethics (CoDE) tailored for this context. Following a comprehensive analysis of existing digital ethics guidelines, we used a reconstructive social research approach to identify 20 relevant principles and derive a code designed as a multi-purpose tool. Versatility was prioritised by defining non-prescriptive guidelines that are open to different perspectives and thus well-suited for operationalisation for varied business purposes. We also chose a clear nested structure that highlights the relationships between five core and fifteen subsidiary principles as well as the different levels of reference—data and algorithmic systems—to which they apply. The CoDE will serve Merck KGaA and its new Digital Ethics Advisory Panel to guide ethical reflection, evaluation and decision-making across the full spectrum of digital developments encountered and undertaken by the company whilst also offering an opportunity to increase transparency for external partners, and thus trust. (shrink)

DeMorgan lattice logic is the consecution version of Anderson/Belnap’s calculus of First Degree Entailments [1]. Theorems of DML are of the form Γ ` A, where Γ is a non-empty set of formulae. Let Γ = {A1, . . . , An}, then Γ ` A is a theorem of DML if and only if A1& . . . &An → A is a theorem of F DE. The Gentzenization of DML offered in this paper, LDML, derives from the worlds (...) semantics for F DE, first presented in [3]. It is for this reason that LDML may be called a “Gentzen semantics” for DML. (shrink)

This paper reviews the origin of inertia according to Mach's principle and Weber's law of gravitation. The resulting theory is based on simultaneous nonlocal gravitational interactions between particles in the solar system and others in the remote universe beyond the Milky Way galaxy. It explains the precession of the perihelion of Mercury. A most important implication of the Mach-Weber theory of the force of inertia is the necessity for a large amount of uniformly distributed matter in the galactic universe. This (...) matter could be the source of the cosmic background radiation. Nonlocal inertia forces are compatible with a static universe and also with an expanding universe but the latter would demand slow changes in the mass of particles and the gravitational constant. (shrink)

The avocado (Persea americana) is a major crop commodity worldwide. Moreover, avocado, a paleopolyploid, is an evolutionary “outpost” among flowering plants, representing a basal lineage (the magnoliid clade) near the origin of the flowering plants themselves. Following centuries of selective breeding, avocado germplasm has been characterized at the level of microsatellite and RFLP markers. Nonetheless, little is known beyond these general diversity estimates, and much work remains to be done to develop avocado as a major subtropical‐zone crop. Among the goals (...) of avocado improvement are to develop varieties with fruit that will “store” better on the tree, show uniform ripening and have better post‐harvest storage. Avocado transcriptome sequencing, genome mapping and partial genomic sequencing will represent a major step toward the goal of sequencing the entire avocado genome, which is expected to aid in improving avocado varieties and production, as well as understanding the evolution of flowers from non‐flowering seed plants (gymnosperms). Additionally, continued evolutionary and other comparative studies of flower and fruit development in different avocado strains can be accomplished at the gene expression level, including in comparison with avocado relatives, and these should provide important insights into the genetic regulation of fruit development in basal angiosperms. BioEssays 30:386–396, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Presenting a fascinating analysis of the idea of what can't be said, this book ascertains whether the notion of there being a truth, or a state of affairs, or knowledge that can't be expressed linguistically is a coherent notion. The author distinguishes different senses in which it might be said that something can't be said. The first part looks at the question of whether ineffability is a coherent idea. Part two evaluates two families of arguments regarding whether ineffable states of (...) affairs actually exist: the argument from mysticism and the argument from epistemic boundedness. Part three looks more closely at the relation between mystic and non-mystic stances. In the fourth and final part the author distinguishes five qualitatively different types of ineffability. _Ineffability and Philosophy_ is a significant contribution to this area of research and will be essential reading for philosophers and those researching and studying the philosophy of language. (shrink)

This volume has 41 chapters written to honor the 100th birthday of Mario Bunge. It celebrates the work of this influential Argentine/Canadian physicist and philosopher. Contributions show the value of Bunge’s science-informed philosophy and his systematic approach to philosophical problems. The chapters explore the exceptionally wide spectrum of Bunge’s contributions to: metaphysics, methodology and philosophy of science, philosophy of mathematics, philosophy of physics, philosophy of psychology, philosophy of social science, philosophy of biology, philosophy of technology, moral philosophy, social and political (...) philosophy, medical philosophy, and education. The contributors include scholars from 16 countries. Bunge combines ontological realism with epistemological fallibilism. He believes that science provides the best and most warranted knowledge of the natural and social world, and that such knowledge is the only sound basis for moral decision making and social and political reform. Bunge argues for the unity of knowledge. In his eyes, science and philosophy constitute a fruitful and necessary partnership. Readers will discover the wisdom of this approach and will gain insight into the utility of cross-disciplinary scholarship. This anthology will appeal to researchers, students, and teachers in philosophy of science, social science, and liberal education programmes. 1. Introduction Section I. An Academic Vocation Section II. Philosophy Section III. Physics and Philosophy of Physics Section IV. Cognitive Science and Philosophy of Mind Section V. Sociology and Social Theory Section VI. Ethics and Political Philosophy Section VII. Biology and Philosophy of Biology Section VIII. Mathematics Section IX. Education Section X. Varia Section XI. Bibliography. (shrink)

Recently advocates of the propensity interpretation of fitness have turned critics. To accommodate examples from the population genetics literature they conclude that fitness is better defined broadly as a family of propensities rather than the propensity to contribute descendants to some future generation. We argue that the propensity theorists have misunderstood the deeper ramifications of the examples they cite. These examples demonstrate why there are factors outside of propensities that determine fitness. We go on to argue for the more general (...) thesis that no account of fitness can satisfy the desiderata that have motivated the propensity account. (shrink)

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

Deep brain stimulation is a well-established therapy for the motor symptoms of Parkinson’s disease, but there remains an opportunity to improve symptom relief. The temporal pattern of stimulation is a new parameter to consider in DBS therapy, and we compared the effectiveness of Temporally Optimized Patterned Stimulation to standard DBS at reducing the motor symptoms of PD. Twenty-six subjects with DBS for PD received three different patterns of stimulation while on medication and using stimulation parameters optimized for standard DBS. Side (...) effects and motor symptoms were assessed after 30 min of stimulation with each pattern. Subjects experienced similar types of side effects with TOPS and standard DBS, and TOPS were well-tolerated by a majority of the subjects. On average, the most effective TOPS was as effective as standard DBS at reducing the motor symptoms of PD. In some subjects a TOPS pattern was the most effective pattern. Finally, the TOPS pattern with low average frequency was found to be as effective or more effective in about half the subjects while substantially reducing estimated stimulation energy use. TOPS DBS may provide a new programing option to improve DBS therapy for PD by improving symptom reduction and/or increasing energy efficiency. Optimizing stimulation parameters specifically for TOPS DBS may demonstrate further clinical benefit of TOPS DBS in treating the motor symptoms of Parkinson’s disease. (shrink)

Under the lig ht of Being and Nothingness’s the o re t ical body – Sartre’s master piece –, it is intended to discuss the essential source of human reality as “n i h i l a t i o n” and ontological lack, as well as manifestations and cons e q u e nces from this primordial human passion to be transformed to coagulated transcendence, to be transformed in Being In-itself-For-itself: to be consciousness and, at the same t i (...) me, to be a complete and finished Being, with infinite de nsity and witho u t fissures. (shrink)

Deviendrai-je le héros de ma propre vie ou ce rôle sera-t-il tenu par un autre? Cette question, inspirée de la littérature, nous interpelle : tout être humain doit trouver sa propre voie, sa manière personnelle de participer à l’aventure humaine. Or, aucun de nous n’est vraiment préparé à se lancer dans un tel périple. Nous n’avons pas choisi notre milieu familial et culturel. Notre corps est fragile, notre pensée faillible. Puis, la route sera parsemée d’embûches de toutes sortes : précipitation, (...) erreur de calcul, malentendu, abandon, chagrin d’amour, injustice, ressentiment, maladie, conflit. Pourtant, nous espérons tous et toutes vivre en paix et avec un minimum de liberté. Pour y parvenir, nous suivrons les chemins qui nous semblent les meilleurs. Comment les choisir? Quelle sera notre boussole? Cet ouvrage porte sur notre quête philosophique d’unité ou d’harmonie. L’auteur y ouvre dix fenêtres sur diverses expériences de vie, de notre premier à notre dernier souffle. (shrink)

In Chapter Five of The Mind Doesn’t Work That Way, Jerry Fodor argues that since it is likely that human minds evolved quickly as saltations rather than gradually as the product of an accumulation of small mutations, evolutionary psychologists are wrong to think that human minds are adaptations. I argue that Fodor’s requirement that adaptationism entails gradualism is wrongheaded. So, while evolutionary psychologists may be wrong to endorse gradualism—and I argue that they are wrong—it does not follow that they are (...) wrong to endorse an adaptationist explanation for how the human mind evolved. (shrink)

Volume 19, Issue 10, October 2019, Page 93-94.

A l'image d'Alain dans ses Propos, André Comte-Sponville réunit 101 des articles qu'il a publié dans divers périodiques, de 1988 à 2010. Ce recueil illustre les principaux axes de sa pensée, et le cheminement personnel d'un penseur qui livre au fur et à mesure de leur apparition, les pensées que lui inspire le monde dans lequel il vit.

Diversität ist eines der zentralen Themen unserer Zeit. Sie durchdringt alle Lebensbereiche unserer Gesellschaften. Das Nachdenken über Diversität reicht von den Naturwissenschaften über die Geschichtswissenschaften, die Gesellschaftswissenschaften, die Philosophie bis zu den Künsten. Diversität ist zudem politisch und emotional beladen. Man denke an gesellschaftliche Minderheiten und ihre Rechte oder an das massive Artensterben unserer Tage. In diesem Buch wird nicht nur über Einzelaspekte von Diversität berichtet, es wird auch eine Synthese versucht. Drei einleitende Kapitel der HerausgeberInnen führen verständlich in komplexe (...) interdisziplinäre Problemzusammenhänge ein. Der Band versammelt 17 Beiträge namhafter Autorinnen und Autoren aus den Bereichen Kunst-, Kultur- und Wissenschaftsgeschichte, Medizin und Gesellschaftstheorie.00. (shrink)

For many years G. E. Moore asked himself what was wrong with sentences like ‘I went to the pictures last Tuesday, but I don't believe that I did’, or ‘I believe that he has gone out, but he has not’. He discussed the problem in 1912 in his Ethics , and was still discussing it in 1944 in a paper to the Moral Sciences Club at Cambridge—an event we know about from a letter of Wittgenstein that I shall quote in (...) a moment. Throughout these years of pondering, Moore retained a remarkably stable vocabulary for setting out his solution. Briefly, he held this: saying ‘I went to the pictures last Tuesday, but I don't believe that I did’ is absurd, but not self-contradictory. Not self-contradictory, because ‘it may quite well be true’; yet absurd, because the speaker expressly repudiates, in the second part of the sentence, a belief which he implies by uttering the first part. The panoply of distinctions which subtends this doctrine—sentence v. utterance of sentence, saying v. implying, contradiction v. absurdity—was subjected to keen scrutiny a generation or so ago, and much of it has now passed into philosophical lore as a discussion of ‘Moore's Paradox’. (shrink)

The T lymphocyte receptor for antigen, which operates in conjunction with gene products of the major histocompatibility complex (MHC), is a molecular complex comprised of five polypeptide chains. Both the 49 kDa alpha and 43 kDa beta chains are immunoglobulin‐like and thus contain variable domains responsible for ligand binding. In contrast, the 20–25 kDa T3 gamma, delta and epsilon chains are monomorphic structures presumably involved in transmembrane signalling. The alpha and beta subunits are disulfide bonded to each other and held (...) in noncovalent association with the T3 chains. T3‐Ti receptor crosslinking leads to conformational modification of a second T lineage specific molecule, termed the 50 kDa T11 structure which in turn leads to protein kinase C activation, elevation in intracytoplasmic free calcium and Na+/H+ antiport stimulation. (shrink)

Traditionally, this puzzle has been solved in various ways. Aristotle, for example, distinguished between “accidental” and “essential” changes. Accidental changes are ones that don't result in a change in an objects' identity after the change, such as when a house is painted, or one's hair turns gray, etc. Aristotle thought of these as changes in the accidental properties of a thing. Essential changes, by contrast, are those which don't preserve the identity of the object when it changes, such as when (...) a house burns to the ground and becomes ashes, or when someone dies. Armed with these distinctions, Aristotle would then say that, in the case of accidental changes, (1) and (2) are both false—a changing thing can really change one of its “accidental properties” and yet literally remain one and the same thing before and after the change. (shrink)

Qu'est-ce que la 'déconstruction'? Quelles sont les origines philosophiques de ce mot magique, brandi par tous ceux dont le but, déclaré ou non, est de criminaliser l'Occident en le réduisant à une expression du racisme, de l'esclavagisme, de l' 'hétéro-patriarcat' et de l'impérialisme colonial? Cette civilisation redoutable dont les proies seraient les peuples dominés, racisés, opprimés, et les minorités essentialisées en tant que victimes systémiques? Ainsi la civilisation occidentale se trouve-t-elle convoquée devant un nouveau grand Tribunal de l'Histoire pour répondre (...) de ses crimes, imaginaires ou réels, et, surtout, elle est la seule civilisation à être mise au banc des accusés. Au croisement de la recherche universitaire et du militantisme politique, le décolonialisme, l'intersectionnalité, la 'théorie critique de la race', la 'théorie queer', la 'théorie du genre', mais aussi le 'wokisme', né d'une corruption idéologique de l'antiracisme et du féminisme importée des campus étatsuniens, se sont peu à peu diffusés dans les médias et dans la société tout entière grâce à une propagande violente et culpabilisante puisant dans un imaginaire victimaire. Dans ce livre incisif et documenté, qui part d'une réflexion sur la pensée de Nietzsche et sur ses mésusages par les disciples français de Heidegger, Pierre-André Taguieff analyse ces théories aussi foisonnantes qu'inconsistantes et dénonce l'émergence de ce nouvel esprit totalitaire qu'il faut se garder de réduire à ses effets les plus médiatisés, comme ces 'déboulonnages' spectaculaires illustrant la violence purificatrice de la 'cancel culture'. De fait, ce néo-puritanisme obscurantiste, inquisitorial et punitif représente, dans les démocraties occidentales, un défi majeur pour les défenseurs de la liberté d'expression, de pensée et de création."--Back cover. (shrink)